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Identification of primary drug resistance to rifampin in Mycobacterium leprae strains from leprosy patients in Amazonas State, Brazil.
Contreras Mejía, Matilde Del Carmen; Porto Dos Santos, Maísa; Villarouco da Silva, George Allan; da Motta Passos, Isabella; Naveca, Felipe Gomes; Souza Cunha, Maria da Graça; Moraes, Milton Ozório; de Paula, Lucia.
Affiliation
  • Contreras Mejía Mdel C; Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Amazonas, Brazil.
  • Porto Dos Santos M; Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Amazonas, Brazil Laboratorio de Micobacteriologia do Instituto Nacional de Pesquisa da Amazônia-INPA, Manaus, Amazonas, Brazil.
  • Villarouco da Silva GA; Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Amazonas, Brazil Fundação Oswaldo Cruz-Instituto Leônidas e Maria Deane, Manaus, Amazonas, Brazil.
  • da Motta Passos I; Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Amazonas, Brazil Universidade Estadual do Amazonas, Manaus, Amazonas, Brazil.
  • Naveca FG; Fundação Oswaldo Cruz-Instituto Leônidas e Maria Deane, Manaus, Amazonas, Brazil.
  • Souza Cunha Mda G; Fundação Alfredo da Matta, Manaus, Amazonas, Brazil.
  • Moraes MO; Laboratório de Hanseníase, Instituto Oswaldo Cruz, FIOCRUZ, Manaus, Amazonas, Brazil.
  • de Paula L; Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Amazonas, Brazil Departamento de Ciências Biológicas, Regional Catalão, Universidade Federal de Goiás, Catalão, Goiás, Brazil lpaula.bio@hotmail.com.
J Clin Microbiol ; 52(12): 4359-60, 2014 Dec.
Article in En | MEDLINE | ID: mdl-25274993
ABSTRACT
The aim of this study was to identify polymorphisms in the folp1, gyrA, and rpoB genes in leprosy patients treated in Amazonas State, Brazil. Among 197 slit-skin smear samples from untreated or relapsed patients, we found three cases of primary resistance to rifampin and one confirmed case of multidrug resistance.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / Drug Resistance, Bacterial / Leprosy / Anti-Bacterial Agents / Mycobacterium leprae Type of study: Diagnostic_studies Limits: Female / Humans / Male Country/Region as subject: America do sul / Brasil Language: En Journal: J Clin Microbiol Year: 2014 Document type: Article Affiliation country: Brazil
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / Drug Resistance, Bacterial / Leprosy / Anti-Bacterial Agents / Mycobacterium leprae Type of study: Diagnostic_studies Limits: Female / Humans / Male Country/Region as subject: America do sul / Brasil Language: En Journal: J Clin Microbiol Year: 2014 Document type: Article Affiliation country: Brazil