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[Influence of surgical technique on graft and endothelial survival in endothelial keratoplasty]. / Influence des techniques chirurgicales de greffe endothéliale sur la survie du greffon et de son endothélium.
Borderie, V M; Georgeon, C; Bouheraoua, N.
Affiliation
  • Borderie VM; CIC 503, CHNO des XV-XX/Inserm/Sorbonne universités, UPMC université Paris 06, 28, rue de Charenton, 75571 Paris cedex 12, France. Electronic address: vincent.borderie@upmc.fr.
  • Georgeon C; CIC 503, CHNO des XV-XX/Inserm/Sorbonne universités, UPMC université Paris 06, 28, rue de Charenton, 75571 Paris cedex 12, France.
  • Bouheraoua N; CIC 503, CHNO des XV-XX/Inserm/Sorbonne universités, UPMC université Paris 06, 28, rue de Charenton, 75571 Paris cedex 12, France.
J Fr Ophtalmol ; 37(9): 675-81, 2014 Nov.
Article in Fr | MEDLINE | ID: mdl-25287818
PURPOSE: To report survival of the graft and its endothelium after Descemet Stripping Endothelial Keratoplasty (DSEK) in a series of consecutive cases with no exclusion of cases corresponding to the learning curve and to analyze the influence of surgical techniques on survival. PATIENTS AND METHODS: This prospective observational study includes 170 consecutive DSEK's performed between 2006 and 2013. The main outcome criteria were graft survival and survival of the donor corneal endothelium as assessed by specular microscopy. The following parameters were analyzed: preoperative diagnosis, lens status, surgical techniques, and graft thickness. RESULTS: Graft survival was 91.7% at 1 year and 71.5% at 3 years. Graft survival was significantly associated with surgical technique (P=0.04). The best graft survival was achieved with scleral incision combined with graft insertion with the Endosaver® device (dedicated DSEK injector). Graft survival decreased with graft thickness (P<0.001). One-year endothelial cell density was significantly associated with surgical technique (P=0.003). Early 1-year endothelial cell loss was 42.0% for the scleral incision/Endosaver® group, 48.7% for the corneal incision/Endosaver® group, 49.4% for the corneal incision/Busin guide group, 66.0% for the corneal incision/IOL injector group, and 66.7% for the scleral incision/forceps group (P=0.002). CONCLUSION: The success rate of DSEK is close to that of penetrating keratoplasty. The use of a DSEK-dedicated injector results in higher survival of the graft and its endothelium. The use of ultrathin grafts also appears to represent significant progress.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endothelial Cells / Descemet Stripping Endothelial Keratoplasty / Graft Survival Type of study: Observational_studies / Risk_factors_studies Limits: Aged / Aged80 / Humans / Middle aged Language: Fr Journal: J Fr Ophtalmol Year: 2014 Document type: Article Country of publication: France

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endothelial Cells / Descemet Stripping Endothelial Keratoplasty / Graft Survival Type of study: Observational_studies / Risk_factors_studies Limits: Aged / Aged80 / Humans / Middle aged Language: Fr Journal: J Fr Ophtalmol Year: 2014 Document type: Article Country of publication: France