Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift.

Medvetz, Doug; Priolo, Carmen; Henske, Elizabeth P

Medvetz, Doug; Priolo, Carmen; Henske, Elizabeth P.

Affiliation

Medvetz D; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Priolo C; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. ehenske@partners.org cpriolo@partners.org.
Henske EP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. ehenske@partners.org cpriolo@partners.org.

Mol Cancer Res ; 13(1): 3-8, 2015 Jan.

Article in En | MEDLINE | ID: mdl-25298408

Subject(s)

Multiprotein Complexes/metabolism; TOR Serine-Threonine Kinases/metabolism; Tuberous Sclerosis/genetics; Tumor Suppressor Proteins/metabolism; Autophagy/genetics; Cell Transformation, Neoplastic/genetics; Humans; Mechanistic Target of Rapamycin Complex 1; Molecular Targeted Therapy; Multiprotein Complexes/biosynthesis; Multiprotein Complexes/genetics; Signal Transduction/genetics; TOR Serine-Threonine Kinases/biosynthesis; TOR Serine-Threonine Kinases/genetics; Tuberous Sclerosis/metabolism; Tuberous Sclerosis/pathology; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberous Sclerosis / Tumor Suppressor Proteins / Multiprotein Complexes / TOR Serine-Threonine Kinases Limits: Humans Language: En Journal: Mol Cancer Res Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2015 Document type: Article Country of publication: United States

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