Combating pathogenic microorganisms using plant-derived antimicrobials: a minireview of the mechanistic basis.
Biomed Res Int
; 2014: 761741, 2014.
Article
in En
| MEDLINE
| ID: mdl-25298964
ABSTRACT
The emergence of antibiotic resistance in pathogenic bacteria has led to renewed interest in exploring the potential of plant-derived antimicrobials (PDAs) as an alternative therapeutic strategy to combat microbial infections. Historically, plant extracts have been used as a safe, effective, and natural remedy for ailments and diseases in traditional medicine. Extensive research in the last two decades has identified a plethora of PDAs with a wide spectrum of activity against a variety of fungal and bacterial pathogens causing infections in humans and animals. Active components of many plant extracts have been characterized and are commercially available; however, research delineating the mechanistic basis of their antimicrobial action is scanty. This review highlights the potential of various plant-derived compounds to control pathogenic bacteria, especially the diverse effects exerted by plant compounds on various virulence factors that are critical for pathogenicity inside the host. In addition, the potential effect of PDAs on gut microbiota is discussed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parasites
/
Plants
/
Bacteria
/
Fungi
/
Anti-Infective Agents
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Biomed Res Int
Year:
2014
Document type:
Article
Affiliation country:
United States