Value of diffusion weighted imaging in the differential diagnosis of benign and malignant breast lesions at 3.0T MRI.
Genet Mol Res
; 13(3): 7773-9, 2014 Sep 26.
Article
in En
| MEDLINE
| ID: mdl-25299091
ABSTRACT
The aim of this study was to investigate the correlation between apparent diffusion coefficients (ADCs), the relative apparent diffusion coefficient (rADC), and the pathological prognostic factor human epidermal growth factor receptor 2 (HER-2) in patients with breast cancer. A total of 64 women with breast cancer underwent breast diffusion-weighted imaging. HER-2 expression was detected in histological specimens. The ADC value, rADC value, and HER-2 level were determined. The ADC and rADC values of the breast cancer group were 1.1495 ± 0.1499 x 10(-3) and 0.6602 ± 0.0853, respectively. The differences in the ADC and rADC values between the two groups were statistically significant. There was no correlation between the ADC value and HER-2 expression in patients with breast cancer (r = -0.508, P = 0.043). However, the rADC value eliminated the individual differences to some extent. Therefore, compared to the ADC value, the rADC value had a better correlation with HER-2 expression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Diseases
/
Breast Neoplasms
/
Diffusion Magnetic Resonance Imaging
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Genet Mol Res
Journal subject:
BIOLOGIA MOLECULAR
/
GENETICA
Year:
2014
Document type:
Article
Affiliation country:
China