Interaction of doxorubicin with a regulatory element of hmga1 and its in vitro anti-cancer activity associated with decreased HMGA1 expression.

Akhter, Md Zahid; Rajeswari, Moganty R

Akhter, Md Zahid; Rajeswari, Moganty R.

Affiliation

Akhter MZ; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: zahidaasim@gmail.com.
Rajeswari MR; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: rajeswari3011@hotmail.com.

J Photochem Photobiol B ; 141: 36-46, 2014 Dec.

Article in En | MEDLINE | ID: mdl-25313540

Subject(s)

Antibiotics, Antineoplastic/chemistry; Doxorubicin/chemistry; HMGA1a Protein/metabolism; Antibiotics, Antineoplastic/metabolism; Antibiotics, Antineoplastic/pharmacology; Apoptosis/drug effects; Apoptosis/radiation effects; Base Sequence; Calorimetry, Differential Scanning; Circular Dichroism; DNA/chemistry; DNA/metabolism; Doxorubicin/metabolism; Doxorubicin/pharmacology; Entropy; Gene Expression/drug effects; Gene Expression/radiation effects; HMGA1a Protein/chemistry; HMGA1a Protein/genetics; Humans; MCF-7 Cells; Promoter Regions, Genetic; RNA, Messenger/metabolism; Regulatory Elements, Transcriptional; Transition Temperature; Ultraviolet Rays

Key words

DNA-drug interaction; Doxorubicin; Spectroscopy; Thermodynamics; hmga1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Doxorubicin / HMGA1a Protein / Antibiotics, Antineoplastic Type of study: Risk_factors_studies Limits: Humans Language: En Journal: J Photochem Photobiol B Journal subject: BIOLOGIA Year: 2014 Document type: Article

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