Determination of a novel nonfluorinated quinolone, nemonoxacin, in human feces and its glucuronide conjugate in human urine and feces by high-performance liquid chromatography-triple quadrupole mass spectrometry.

He, Gaoli; Guo, Beining; Yu, Jicheng; Zhang, Jing; Wu, Xiaojie; Cao, Guoying; Shi, Yaoguo; Tsai, Cheng-Yuan

He, Gaoli; Guo, Beining; Yu, Jicheng; Zhang, Jing; Wu, Xiaojie; Cao, Guoying; Shi, Yaoguo; Tsai, Cheng-Yuan.

Affiliation

He G; Institute of Antibiotics, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd, Shanghai, 200040, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, 12 Wulumuqi Zhong Rd, Shanghai, 200040, China.

Biomed Chromatogr ; 29(5): 739-48, 2015 May.

Article in En | MEDLINE | ID: mdl-25322721

Subject(s)

Chromatography, High Pressure Liquid/methods; Feces/chemistry; Glucuronides/analysis; Quinolines/analysis; Quinolones/analysis; Tandem Mass Spectrometry/methods; Glucuronides/urine; Humans; Quinolines/urine; Quinolones/urine

Key words

LC-MS/MS; human urine and feces; metabolite; nemonoxacin; validation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Chromatography, High Pressure Liquid / Quinolones / Glucuronides / Tandem Mass Spectrometry / Feces Type of study: Evaluation_studies Limits: Humans Language: En Journal: Biomed Chromatogr Year: 2015 Document type: Article Affiliation country: China Country of publication: United kingdom

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