A pharmacogenetic association between a variation in calpain 10 (CAPN10) gene and the response to metformin treatment in patients with type 2 diabetes.

Tkác, Ivan; Javorský, Martin; Klimcáková, Lucia; Zidzik, Jozef; Gala, Igor; Babjaková, Eva; Schroner, Zbynek; Stolfová, Mária; Hermanová, Hana; Habalová, Viera

Tkác, Ivan; Javorský, Martin; Klimcáková, Lucia; Zidzik, Jozef; Gala, Igor; Babjaková, Eva; Schroner, Zbynek; Stolfová, Mária; Hermanová, Hana; Habalová, Viera.

Affiliation

Tkác I; Department of Internal Medicine 4, Faculty of Medicine, P. J. Safárik University, Rastislavova 43, 04190, Kosice, Slovakia, ivan.tkac@upjs.sk.

Eur J Clin Pharmacol ; 71(1): 59-63, 2015 Jan.

Article in En | MEDLINE | ID: mdl-25327507

Subject(s)

Calpain/genetics; Diabetes Mellitus, Type 2/drug therapy; Diabetes Mellitus, Type 2/genetics; Hypoglycemic Agents/therapeutic use; Metformin/therapeutic use; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases/genetics; Diabetes Mellitus, Type 2/blood; Female; Genetic Variation; Glycated Hemoglobin/analysis; Hepatocyte Nuclear Factor 1-alpha/genetics; Humans; Intracellular Signaling Peptides and Proteins/genetics; Male; Middle Aged; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphoenolpyruvate Carboxykinase (GTP)/genetics; Protein Serine-Threonine Kinases/genetics; Transcription Factors/genetics; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calpain / Diabetes Mellitus, Type 2 / Hypoglycemic Agents / Metformin Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Eur J Clin Pharmacol Year: 2015 Document type: Article Country of publication: Germany

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