Axonally derived matrilin-2 induces proinflammatory responses that exacerbate autoimmune neuroinflammation.

Jonas, Anna; Thiem, Stefan; Kuhlmann, Tanja; Wagener, Raimund; Aszodi, Attila; Nowell, Cameron; Hagemeier, Karin; Laverick, Louise; Perreau, Victoria; Jokubaitis, Vilija; Emery, Ben; Kilpatrick, Trevor; Butzkueven, Helmut; Gresle, Melissa

Jonas, Anna; Thiem, Stefan; Kuhlmann, Tanja; Wagener, Raimund; Aszodi, Attila; Nowell, Cameron; Hagemeier, Karin; Laverick, Louise; Perreau, Victoria; Jokubaitis, Vilija; Emery, Ben; Kilpatrick, Trevor; Butzkueven, Helmut; Gresle, Melissa.

J Clin Invest ; 124(11): 5042-56, 2014 Nov.

Article in En | MEDLINE | ID: mdl-25329699

Subject(s)

Encephalomyelitis, Autoimmune, Experimental/metabolism; Animals; Axons/immunology; Axons/metabolism; Cells, Cultured; Coculture Techniques; Female; Humans; Immunity, Innate; Inflammation Mediators/metabolism; Macrophages/immunology; Macrophages/metabolism; Male; Matrilin Proteins/physiology; Mice, Inbred C57BL; Mice, Knockout; Motor Cortex/metabolism; Signal Transduction; Spinal Cord Injuries/metabolism; Toll-Like Receptor 4/metabolism; Transcriptional Activation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Encephalomyelitis, Autoimmune, Experimental Limits: Animals / Female / Humans / Male Language: En Journal: J Clin Invest Year: 2014 Document type: Article Country of publication: United States

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