Association between serrated polyps and the risk of synchronous advanced colorectal neoplasia in average-risk individuals.
Aliment Pharmacol Ther
; 41(1): 108-15, 2015 Jan.
Article
in En
| MEDLINE
| ID: mdl-25339583
ABSTRACT
BACKGROUND:
Serrated polyps of the colorectum have distinct histological features and malignant potential.AIM:
To assess the association between the presence of serrated polyps and synchronous advanced colorectal neoplasia.METHODS:
Among 4989 asymptomatic Chinese individuals aged 50-70 years who underwent screening colonoscopy, 281 cases with advanced neoplasia (adenoma ≥1 cm, with tubulovillous/villous histology, with high-grade dysplasia, or invasive adenocarcinoma) were compared with 4708 controls without advanced neoplasia for age, sex, smoking history, body mass index, family history of colorectal cancer and the presence of serrated polyps. Independent predictors of advanced neoplasia were determined by multivariate logistic regression analysis.RESULTS:
The prevalence of advanced neoplasia and serrated polyps (excluding small distal hyperplastic polyps) was 5.7% and 5.6%, respectively. 3.7% and 0.4% subjects had proximal and large (≥10 mm) serrated polyps, respectively. Independent predictors of synchronous advanced colorectal neoplasia were the presence of sessile serrated adenomas (OR 4.52; 95% CI 2.40-8.49), proximal serrated polyps (OR 2.23, 95% CI 1.38-3.60), large serrated polyps (OR 59.25; 95% CI 18.85-186.21), hyperplastic polyps (OR 1.66; 95% CI 1.03-2.67), three or more serrated polyps (OR 4.86; 95% CI 1.24-19.15) and one or more non-advanced tubular adenomas (OR 3.58, 95% CI 2.59-4.96).CONCLUSION:
Detection of proximal, sessile and/or large serrated polyps at screening colonoscopy is independently associated with an increased risk for synchronous advanced neoplasia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Colorectal Neoplasms
/
Adenocarcinoma
/
Adenoma
/
Colonic Polyps
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Aliment Pharmacol Ther
Journal subject:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2015
Document type:
Article
Affiliation country:
China