euL1db: the European database of L1HS retrotransposon insertions in humans.
Nucleic Acids Res
; 43(Database issue): D43-7, 2015 Jan.
Article
in En
| MEDLINE
| ID: mdl-25352549
ABSTRACT
Retrotransposons account for almost half of our genome. They are mobile genetics elements-also known as jumping genes--but only the L1HS subfamily of Long Interspersed Nuclear Elements (LINEs) has retained the ability to jump autonomously in modern humans. Their mobilization in germline--but also some somatic tissues--contributes to human genetic diversity and to diseases, such as cancer. Here, we present euL1db, the European database of L1HS retrotransposon insertions in humans (available at http//euL1db.unice.fr). euL1db provides a curated and comprehensive summary of L1HS insertion polymorphisms identified in healthy or pathological human samples and published in peer-reviewed journals. A key feature of euL1db is its sample--wise organization. Hence L1HS insertion polymorphisms are connected to samples, individuals, families and clinical conditions. The current version of euL1db centralizes results obtained in 32 studies. It contains >900 samples, >140,000 sample-wise insertions and almost 9000 distinct merged insertions. euL1db will help understanding the link between L1 retrotransposon insertion polymorphisms and phenotype or disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Long Interspersed Nucleotide Elements
/
Databases, Nucleic Acid
Limits:
Humans
Language:
En
Journal:
Nucleic Acids Res
Year:
2015
Document type:
Article
Affiliation country:
France