Ionizable amphiphilic dendrimer-based nanomaterials with alkyl-chain-substituted amines for tunable siRNA delivery to the liver endothelium in vivo.

Khan, Omar F; Zaia, Edmond W; Yin, Hao; Bogorad, Roman L; Pelet, Jeisa M; Webber, Matthew J; Zhuang, Iris; Dahlman, James E; Langer, Robert; Anderson, Daniel G

Khan, Omar F; Zaia, Edmond W; Yin, Hao; Bogorad, Roman L; Pelet, Jeisa M; Webber, Matthew J; Zhuang, Iris; Dahlman, James E; Langer, Robert; Anderson, Daniel G.

Affiliation

Khan OF; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA).

Angew Chem Int Ed Engl ; 53(52): 14397-401, 2014 Dec 22.

Article in En | MEDLINE | ID: mdl-25354018

Subject(s)

Amines/chemistry; Dendrimers/chemistry; RNA, Small Interfering/metabolism; Cell Line, Tumor; Endothelial Cells/cytology; Endothelial Cells/metabolism; Factor VII/antagonists & inhibitors; Factor VII/genetics; Factor VII/metabolism; HeLa Cells; Humans; Liver/cytology; Nanostructures/chemistry; RNA Interference; Transfection; alpha-Fetoproteins/antagonists & inhibitors; alpha-Fetoproteins/genetics; alpha-Fetoproteins/metabolism

Key words

RNA; amphiphiles; dendrimers; drug delivery; nanomaterials

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Small Interfering / Dendrimers / Amines Limits: Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2014 Document type: Article Country of publication: Germany

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