Development of organometallic S6K1 inhibitors.

Qin, Jie; Rajaratnam, Rajathees; Feng, Li; Salami, Jemilat; Barber-Rotenberg, Julie S; Domsic, John; Reyes-Uribe, Patricia; Liu, Haiying; Dang, Weiwei; Berger, Shelley L; Villanueva, Jessie; Meggers, Eric; Marmorstein, Ronen

Qin, Jie; Rajaratnam, Rajathees; Feng, Li; Salami, Jemilat; Barber-Rotenberg, Julie S; Domsic, John; Reyes-Uribe, Patricia; Liu, Haiying; Dang, Weiwei; Berger, Shelley L; Villanueva, Jessie; Meggers, Eric; Marmorstein, Ronen.

Affiliation

Qin J; The Wistar Institute , 3601 Spruce Street, Philadelphia, Pennsylvania 19104, United States.

J Med Chem ; 58(1): 305-14, 2015 Jan 08.

Article in En | MEDLINE | ID: mdl-25356520

Subject(s)

Organometallic Compounds/chemistry; Protein Kinase Inhibitors/chemistry; Ribosomal Protein S6 Kinases, 70-kDa/chemistry; Adenosine Triphosphate/chemistry; Adenosine Triphosphate/metabolism; Binding Sites; Blotting, Western; Cell Line, Tumor; Drug Discovery; HEK293 Cells; Humans; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Molecular Structure; Organometallic Compounds/metabolism; Organometallic Compounds/pharmacology; Phosphorylation/drug effects; Protein Binding; Protein Kinase Inhibitors/metabolism; Protein Kinase Inhibitors/pharmacology; Protein Structure, Secondary; Protein Structure, Tertiary; Ribosomal Protein S6 Kinases, 70-kDa/antagonists & inhibitors; Ribosomal Protein S6 Kinases, 70-kDa/metabolism; Ruthenium/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organometallic Compounds / Ribosomal Protein S6 Kinases, 70-kDa / Protein Kinase Inhibitors Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States

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