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Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.
Borcherds, Wade; Theillet, François-Xavier; Katzer, Andrea; Finzel, Ana; Mishall, Katie M; Powell, Anne T; Wu, Hongwei; Manieri, Wanda; Dieterich, Christoph; Selenko, Philipp; Loewer, Alexander; Daughdrill, Gary W.
Affiliation
  • Borcherds W; 1] Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA. [2] Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA.
  • Theillet FX; In-cell NMR Laboratory, Department of NMR-supported Structural Biology, Leibniz Institute of Molecular Pharmacology (FMP Berlin), Berlin, Germany.
  • Katzer A; Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
  • Finzel A; Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
  • Mishall KM; 1] Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA. [2] Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA.
  • Powell AT; 1] Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA. [2] Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA.
  • Wu H; 1] Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA. [2] Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA.
  • Manieri W; Drug Discovery Department, Moffitt Cancer Center, University of South Florida, Tampa, Florida, USA.
  • Dieterich C; Max Planck Institute for Biology of Ageing, Cologne, Germany.
  • Selenko P; In-cell NMR Laboratory, Department of NMR-supported Structural Biology, Leibniz Institute of Molecular Pharmacology (FMP Berlin), Berlin, Germany.
  • Loewer A; Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
  • Daughdrill GW; 1] Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA. [2] Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA.
Nat Chem Biol ; 10(12): 1000-2, 2014 Dec.
Article in En | MEDLINE | ID: mdl-25362358
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-mdm2 / Intrinsically Disordered Proteins Limits: Humans Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-mdm2 / Intrinsically Disordered Proteins Limits: Humans Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States