Polyaspartamide-doxorubicin conjugate as potential prodrug for anticancer therapy.

Di Meo, Chiara; Cilurzo, Felisa; Licciardi, Mariano; Scialabba, Cinzia; Sabia, Rocchina; Paolino, Donatella; Capitani, Donatella; Fresta, Massimo; Giammona, Gaetano; Villani, Claudio; Matricardi, Pietro

Di Meo, Chiara; Cilurzo, Felisa; Licciardi, Mariano; Scialabba, Cinzia; Sabia, Rocchina; Paolino, Donatella; Capitani, Donatella; Fresta, Massimo; Giammona, Gaetano; Villani, Claudio; Matricardi, Pietro.

Affiliation

Di Meo C; Department of Drug Chemistry and Technologies, "Sapienza" University of Rome, P.le Aldo Moro 5, 00185, Rome, Italy.

Pharm Res ; 32(5): 1557-69, 2015 May.

Article in En | MEDLINE | ID: mdl-25366547

Subject(s)

Aspartame/analogs & derivatives; Breast Neoplasms/drug therapy; Doxorubicin/analogs & derivatives; Doxorubicin/therapeutic use; Polyamines/chemistry; Polyamines/therapeutic use; Prodrugs/chemistry; Prodrugs/therapeutic use; Animals; Aspartame/chemistry; Aspartame/pharmacokinetics; Aspartame/therapeutic use; Breast/drug effects; Breast/pathology; Breast Neoplasms/pathology; Cell Line, Tumor; Doxorubicin/pharmacokinetics; Female; Humans; MCF-7 Cells; Mice, Inbred NOD; Mice, SCID; Polyamines/pharmacokinetics; Prodrugs/pharmacokinetics; Tissue Distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyamines / Aspartame / Breast Neoplasms / Prodrugs / Doxorubicin Limits: Animals / Female / Humans Language: En Journal: Pharm Res Year: 2015 Document type: Article Affiliation country: Italy Country of publication: United States

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