Next-generation sequencing studies guide the design of pyrrole-imidazole polyamides with improved binding specificity by the addition of ß-alanine.

Anandhakumar, Chandran; Li, Yue; Kizaki, Seiichiro; Pandian, Ganesh N; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi

Anandhakumar, Chandran; Li, Yue; Kizaki, Seiichiro; Pandian, Ganesh N; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi.

Affiliation

Anandhakumar C; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan).

Chembiochem ; 15(18): 2647-51, 2014 Dec 15.

Article in En | MEDLINE | ID: mdl-25371287

Subject(s)

DNA/metabolism; Imidazoles/chemistry; Nylons/chemistry; Pyrroles/chemistry; beta-Alanine/chemistry; Base Sequence; Binding Sites; DNA/chemistry; High-Throughput Nucleotide Sequencing; Imidazoles/metabolism; Nylons/metabolism; Pyrroles/metabolism; beta-Alanine/metabolism

Key words

DNA recognition; high throughput screening; next generation sequencing; synthetic biology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / DNA / Beta-Alanine / Imidazoles / Nylons Type of study: Prognostic_studies Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2014 Document type: Article Country of publication: Germany

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