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Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.
Yu, Y Joy; Atwal, Jasvinder K; Zhang, Yin; Tong, Raymond K; Wildsmith, Kristin R; Tan, Christine; Bien-Ly, Nga; Hersom, Maria; Maloney, Janice A; Meilandt, William J; Bumbaca, Daniela; Gadkar, Kapil; Hoyte, Kwame; Luk, Wilman; Lu, Yanmei; Ernst, James A; Scearce-Levie, Kimberly; Couch, Jessica A; Dennis, Mark S; Watts, Ryan J.
Affiliation
  • Yu YJ; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Atwal JK; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Zhang Y; Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.
  • Tong RK; Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
  • Wildsmith KR; Development Sciences, Genentech Inc., South San Francisco, CA 94080, USA.
  • Tan C; Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.
  • Bien-Ly N; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Hersom M; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Maloney JA; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Meilandt WJ; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Bumbaca D; Development Sciences, Genentech Inc., South San Francisco, CA 94080, USA.
  • Gadkar K; Development Sciences, Genentech Inc., South San Francisco, CA 94080, USA.
  • Hoyte K; Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.
  • Luk W; Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.
  • Lu Y; Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.
  • Ernst JA; Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
  • Scearce-Levie K; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Couch JA; Development Sciences, Genentech Inc., South San Francisco, CA 94080, USA.
  • Dennis MS; Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.
  • Watts RJ; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. rwatts@gene.com.
Sci Transl Med ; 6(261): 261ra154, 2014 Nov 05.
Article in En | MEDLINE | ID: mdl-25378646
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Transferrin / Capillary Permeability / Blood-Brain Barrier / Antigens, CD / Aspartic Acid Endopeptidases / Antibodies, Bispecific / Amyloid Precursor Protein Secretases Limits: Animals / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2014 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Transferrin / Capillary Permeability / Blood-Brain Barrier / Antigens, CD / Aspartic Acid Endopeptidases / Antibodies, Bispecific / Amyloid Precursor Protein Secretases Limits: Animals / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2014 Document type: Article Affiliation country: United States