Monocyte chemoattractant protein 1 (MCP-1/CCL2) contributes to thymus atrophy in acute myeloid leukemia.

Driss, Virginie; Quesnel, Bruno; Brinster, Carine

Driss, Virginie; Quesnel, Bruno; Brinster, Carine.

Affiliation

Driss V; Institut pour la Recherche sur le Cancer de Lille (IRCL), INSERM U.837, Lille Cedex, France.

Eur J Immunol ; 45(2): 396-406, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25382729

Subject(s)

Antibodies, Neutralizing/pharmacology; CD4-Positive T-Lymphocytes/pathology; CD8-Positive T-Lymphocytes/pathology; Chemokine CCL2/antagonists & inhibitors; Leukemia, Myeloid, Acute/drug therapy; Thymus Gland/drug effects; Animals; Atrophy; CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/immunology; Chemokine CCL2/genetics; Chemokine CCL2/immunology; Disease Models, Animal; Female; Forkhead Transcription Factors/genetics; Forkhead Transcription Factors/immunology; Gene Expression; Humans; Immunologic Memory; Leukemia, Myeloid, Acute/immunology; Leukemia, Myeloid, Acute/mortality; Leukemia, Myeloid, Acute/pathology; Lymphocyte Count; Mice; Mice, Inbred Strains; Organ Size; Survival Analysis; Thymectomy; Thymus Gland/immunology; Thymus Gland/pathology

Key words

Acute myeloid leukemia; MCP-1/CCL2; T-cell response; mouse model; thymus

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymus Gland / Leukemia, Myeloid, Acute / CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / Chemokine CCL2 / Antibodies, Neutralizing Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Eur J Immunol Year: 2015 Document type: Article Affiliation country: France Country of publication: Germany

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