Secondary mutations at I1171 in the ALK gene confer resistance to both Crizotinib and Alectinib.

Toyokawa, Gouji; Hirai, Fumihiko; Inamasu, Eiko; Yoshida, Tsukihisa; Nosaki, Kaname; Takenaka, Tomoyoshi; Yamaguchi, Masafumi; Seto, Takashi; Takenoyama, Mitsuhiro; Ichinose, Yukito

Toyokawa, Gouji; Hirai, Fumihiko; Inamasu, Eiko; Yoshida, Tsukihisa; Nosaki, Kaname; Takenaka, Tomoyoshi; Yamaguchi, Masafumi; Seto, Takashi; Takenoyama, Mitsuhiro; Ichinose, Yukito.

Affiliation

Toyokawa G; Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan.

J Thorac Oncol ; 9(12): e86-7, 2014 Dec.

Article in En | MEDLINE | ID: mdl-25393798

Subject(s)

Bone Neoplasms/secondary; Brain Neoplasms/secondary; Carcinoma, Non-Small-Cell Lung/drug therapy; Carcinoma, Non-Small-Cell Lung/genetics; Lung Neoplasms/drug therapy; Mutation; Pyrazoles/therapeutic use; Pyridines/therapeutic use; Receptor Protein-Tyrosine Kinases/genetics; Adult; Anaplastic Lymphoma Kinase; Bone Neoplasms/drug therapy; Brain Neoplasms/drug therapy; Carbazoles/therapeutic use; Carcinoma, Non-Small-Cell Lung/enzymology; Carcinoma, Non-Small-Cell Lung/pathology; Clinical Trials, Phase III as Topic; Crizotinib; Drug Resistance, Multiple; Female; Gene Fusion; Humans; Lung Neoplasms/enzymology; Lung Neoplasms/genetics; Lung Neoplasms/pathology; Piperidines/therapeutic use; Protein Kinase Inhibitors/therapeutic use; Randomized Controlled Trials as Topic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyridines / Bone Neoplasms / Brain Neoplasms / Receptor Protein-Tyrosine Kinases / Carcinoma, Non-Small-Cell Lung / Lung Neoplasms / Mutation Type of study: Clinical_trials Limits: Adult / Female / Humans Language: En Journal: J Thorac Oncol Year: 2014 Document type: Article Affiliation country: Japan

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