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MethHC: a database of DNA methylation and gene expression in human cancer.
Huang, Wei-Yun; Hsu, Sheng-Da; Huang, Hsi-Yuan; Sun, Yi-Ming; Chou, Chih-Hung; Weng, Shun-Long; Huang, Hsien-Da.
Affiliation
  • Huang WY; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu 300, Taiwan Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu 300, Taiwan.
  • Hsu SD; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu 300, Taiwan.
  • Huang HY; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu 300, Taiwan.
  • Sun YM; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu 300, Taiwan.
  • Chou CH; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu 300, Taiwan Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu 300, Taiwan.
  • Weng SL; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu 300, Taiwan Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu 300, Taiwan Department of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsin-Chu 300, Taiwan
  • Huang HD; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu 300, Taiwan Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu 300, Taiwan Center for Bioinformatics Research, National Chiao Tung University, Hsin-Chu 300, Taiwan Departm
Nucleic Acids Res ; 43(Database issue): D856-61, 2015 Jan.
Article in En | MEDLINE | ID: mdl-25398901
ABSTRACT
We present MethHC (http//MethHC.mbc.nctu.edu.tw), a database comprising a systematic integration of a large collection of DNA methylation data and mRNA/microRNA expression profiles in human cancer. DNA methylation is an important epigenetic regulator of gene transcription, and genes with high levels of DNA methylation in their promoter regions are transcriptionally silent. Increasing numbers of DNA methylation and mRNA/microRNA expression profiles are being published in different public repositories. These data can help researchers to identify epigenetic patterns that are important for carcinogenesis. MethHC integrates data such as DNA methylation, mRNA expression, DNA methylation of microRNA gene and microRNA expression to identify correlations between DNA methylation and mRNA/microRNA expression from TCGA (The Cancer Genome Atlas), which includes 18 human cancers in more than 6000 samples, 6548 microarrays and 12 567 RNA sequencing data.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Methylation / Databases, Genetic / Transcriptome / Neoplasms Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2015 Document type: Article Affiliation country: Taiwan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Methylation / Databases, Genetic / Transcriptome / Neoplasms Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2015 Document type: Article Affiliation country: Taiwan