Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ ß-arrestin-1 dependent manner in NSCLC.

Perumal, Deepak; Pillai, Smitha; Nguyen, Jonathan; Schaal, Courtney; Coppola, Domenico; Chellappan, Srikumar P

Perumal, Deepak; Pillai, Smitha; Nguyen, Jonathan; Schaal, Courtney; Coppola, Domenico; Chellappan, Srikumar P.

Affiliation

Perumal D; Department of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, Magnolia Drive, Tampa, FL, USA. Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, USA.
Pillai S; Department of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, Magnolia Drive, Tampa, FL, USA.
Nguyen J; Department of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, Magnolia Drive, Tampa, FL, USA.
Schaal C; Department of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, Magnolia Drive, Tampa, FL, USA.
Coppola D; Department of Anatomic Pathology, H. Lee Moffitt Cancer Center & Research Institute, Magnolia Drive, Tampa, FL, USA.
Chellappan SP; Department of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, Magnolia Drive, Tampa, FL, USA.

Oncotarget ; 5(21): 10486-502, 2014 Nov 15.

Article in En | MEDLINE | ID: mdl-25401222

Subject(s)

Arrestins/metabolism; Carcinoma, Non-Small-Cell Lung/secondary; E2F1 Transcription Factor/metabolism; Neoplastic Stem Cells/pathology; Receptors, Nicotinic/metabolism; Stem Cell Factor/metabolism; Adenocarcinoma/metabolism; Adenocarcinoma/mortality; Adenocarcinoma/secondary; Arrestins/antagonists & inhibitors; Arrestins/genetics; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Carcinoma, Non-Small-Cell Lung/metabolism; Carcinoma, Non-Small-Cell Lung/mortality; Carcinoma, Squamous Cell/metabolism; Carcinoma, Squamous Cell/mortality; Carcinoma, Squamous Cell/secondary; Chromatin Immunoprecipitation; E2F1 Transcription Factor/antagonists & inhibitors; E2F1 Transcription Factor/genetics; Enzyme-Linked Immunosorbent Assay; Gene Expression Profiling; Humans; Immunoenzyme Techniques; Lung Neoplasms/metabolism; Lung Neoplasms/mortality; Lung Neoplasms/pathology; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Mas; RNA, Messenger/genetics; RNA, Small Interfering/genetics; Real-Time Polymerase Chain Reaction; Receptors, Nicotinic/genetics; Reverse Transcriptase Polymerase Chain Reaction; Smoking; Stem Cell Factor/genetics; Tumor Cells, Cultured; beta-Arrestin 1; beta-Arrestins

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Receptors, Nicotinic / Carcinoma, Non-Small-Cell Lung / Stem Cell Factor / Arrestins / E2F1 Transcription Factor Type of study: Prognostic_studies Language: En Journal: Oncotarget Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google