[Genomics from bench to bedside: a change in perspective]. / Génomique, de la recherche à la clinique - questions autour d'un changement de perspective.
Med Sci (Paris)
; 30 Spec No 2: 14-7, 2014 Nov.
Article
in Fr
| MEDLINE
| ID: mdl-25407452
ABSTRACT
While genomics is sometimes presented as an area of ââresearch where results can be rapidly translated into clinical practice, the facts are more ambiguous. To illustrate some of the pitfalls of translation, this article focuses on the applications of genome-wide association studies (GWAS) results. Following a brief scientific contextualization of GWAS, two emblematic examples are presented as illustrations. The case of Crohn's disease emphasizes the limits of GWAS results for individual risk prediction. The case of warfarin highlights the difficulties of demonstrating the clinical utility of genetic data in treatment decisions. The article outlines the simplification of disease causation that underlies the GWAS methodology. Whereas this reductionist approach is fruitful for exploratory research purposes, it shows its limits when applied to clinical conditions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genome, Human
/
Precision Medicine
/
Translational Research, Biomedical
Type of study:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Fr
Journal:
Med Sci (Paris)
Journal subject:
MEDICINA
Year:
2014
Document type:
Article
Affiliation country:
France