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Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target.
Gurcha, Sudagar S; Usha, Veeraraghavan; Cox, Jonathan A G; Fütterer, Klaus; Abrahams, Katherine A; Bhatt, Apoorva; Alderwick, Luke J; Reynolds, Robert C; Loman, Nicholas J; Nataraj, VijayaShankar; Alemparte, Carlos; Barros, David; Lloyd, Adrian J; Ballell, Lluis; Hobrath, Judith V; Besra, Gurdyal S.
Affiliation
  • Gurcha SS; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
  • Usha V; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
  • Cox JA; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
  • Fütterer K; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
  • Abrahams KA; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
  • Bhatt A; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
  • Alderwick LJ; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
  • Reynolds RC; Department of Chemistry, University of Alabama at Birmingham, College of Arts and Sciences, 1530 3rd Avenue South, Birmingham, Alabama, 35294-1240, United States of America.
  • Loman NJ; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
  • Nataraj V; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
  • Alemparte C; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain.
  • Barros D; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain.
  • Lloyd AJ; Department of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.
  • Ballell L; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain.
  • Hobrath JV; Organic Chemistry Department, Southern Research Institute, Birmingham, Alabama, 35205, United States of America.
  • Besra GS; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
PLoS One ; 9(11): e113568, 2014.
Article in En | MEDLINE | ID: mdl-25409504
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Aspartate-tRNA Ligase / Thiazoles / Mycobacterium bovis / Mycobacterium tuberculosis / Antitubercular Agents Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2014 Document type: Article Affiliation country: United kingdom Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Aspartate-tRNA Ligase / Thiazoles / Mycobacterium bovis / Mycobacterium tuberculosis / Antitubercular Agents Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2014 Document type: Article Affiliation country: United kingdom Country of publication: United States