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Association of residual plasma viremia and intima-media thickness in antiretroviral-treated patients with controlled human immunodeficiency virus infection.
Boyd, Anders; Meynard, Jean-Luc; Morand-Joubert, Laurence; Michon, Adrien; Boccara, Franck; Bastard, Jean-Philippe; Samri, Assia; Haddour, Nabila; Mallat, Ziad; Capeau, Jacqueline; Desvarieux, Moïse; Girard, Pierre-Marie.
Affiliation
  • Boyd A; INSERM UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
  • Meynard JL; Sorbonne Université, UPMC Univ Paris-6, Paris, France; Department of Infectious and Tropical Diseases, Hôpital Saint-Antoine, AP-HP, Paris, France.
  • Morand-Joubert L; Sorbonne Universités, UPMC Univ Paris 06, INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Laboratoire de Virologie, Saint Antoine, APHP, Paris, France.
  • Michon A; Service de médecine interne, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
  • Boccara F; Sorbonne Université, UPMC Univ Paris-6, Paris, France; Department of Cardiology, Hôpital Saint-Antoine, AP-HP, Paris, France; INSERM UMR_S 938, Paris, France.
  • Bastard JP; Sorbonne Université, UPMC Univ Paris-6, Paris, France; APHP, Hôpital Tenon, Service de biochimie et hormonologie, Inserm UMR_S938, and Institute of Cardiometabolism and Nutrition, Paris, France.
  • Samri A; Sorbonne Université, UPMC Univ Paris-6, Paris, France; Inserm, UMR-S945, IFR113, Department of Immunology, Paris, France.
  • Haddour N; Sorbonne Université, UPMC Univ Paris-6, Paris, France; Department of Cardiology, Hôpital Saint-Antoine, AP-HP, Paris, France.
  • Mallat Z; Inserm U970, Cardiovascular Research Center, and Université Paris-Descartes University, Paris, France; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Capeau J; Sorbonne Université, UPMC Univ Paris-6, Paris, France; APHP, Hôpital Tenon, Service de biochimie et hormonologie, Inserm UMR_S938, and Institute of Cardiometabolism and Nutrition, Paris, France.
  • Desvarieux M; Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, New York, United States of America; Inserm U738 and Ecole des Hautes Études en Santé Publique, Paris, France.
  • Girard PM; INSERM UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France; Sorbonne Université, UPMC Univ Paris-6, Paris, France; Department of Infectious and Tropical Diseases, Hôpital Saint-Antoine, AP-HP, Paris, France.
PLoS One ; 9(11): e113876, 2014.
Article in En | MEDLINE | ID: mdl-25415323
BACKGROUND: While residual plasma viremia is commonly observed in HIV-infected patients undergoing antiretroviral treatment (ART), little is known about its subclinical consequences. METHODS: This cross-sectional study included 47 male, never-smoking, non-diabetic patients with ≥4 years of ART and controlled HIV-replication (HIV-viral load, VL <20 copies/mL for ≥1 year). Residual HIV-VL was measured using an ultrasensitive assay (quantification limit: 1 copy/ml). Patients were categorized as having detectable (D; 1-20 copies/mL, n = 14) or undetectable (UD; <1 copies/mL, n = 33) HIV-VL. Linear regression was used to model the difference in total carotid intima-media thickness [c-IMT, measures averaged across common carotid artery (cca), bifurcation, and internal carotid artery] and cca-IMT alone across detection groups. Multivariable models were constructed for each endpoint in a forward-stepwise approach. RESULTS: No significant differences were observed between viremia groups with respect to median ART-duration (9.6 years, IQR = 6.8-10.9), nadir CD4+T-cell (208/mm3, IQR = 143-378), and CD4+T-cell count (555/mm3, IQR = 458-707). Median adjusted inflammatory markers tended to be higher in patients with D- than UD-viremia, with differences in IL-10 being significant (p = 0.03). After adjustment on age, systolic blood pressure, and insulin resistance, mean cca-IMT was significantly lower in patients with undetectable (0.668 mm±0.010) versus detectable viremia (0.727 mm±0.015, p = 0.002). Cca-IMT was also independently associated with age and insulin resistance. Mean adjusted total c-IMT was no different between viremia groups (p = 0.2), however there was large variability in bifurcation c-IMT measurements. CONCLUSIONS: Higher cca-IMT was observed in patients with detectable, compared to undetectable, HIV-VL in never-smoking ART-controlled patients, suggesting that residual HIV viremia may be linked to atherosclerosis.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viremia / HIV Infections / HIV-1 / Carotid Artery, Common / Anti-Retroviral Agents / Carotid Intima-Media Thickness Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Humans / Male / Middle aged Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2014 Document type: Article Affiliation country: France Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viremia / HIV Infections / HIV-1 / Carotid Artery, Common / Anti-Retroviral Agents / Carotid Intima-Media Thickness Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Humans / Male / Middle aged Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2014 Document type: Article Affiliation country: France Country of publication: United States