Kinase activity profiling reveals active signal transduction pathways in pediatric acute lymphoblastic leukemia: a new approach for target discovery.

van der Sligte, Naomi E; Scherpen, Frank J G; Meeuwsen-de Boer, Tiny G J; Lourens, Harm Jan; Ter Elst, Arja; Diks, Sander H; Guryev, Victor; Peppelenbosch, Maikel P; van Leeuwen, Frank N; de Bont, Eveline S J M

van der Sligte, Naomi E; Scherpen, Frank J G; Meeuwsen-de Boer, Tiny G J; Lourens, Harm Jan; Ter Elst, Arja; Diks, Sander H; Guryev, Victor; Peppelenbosch, Maikel P; van Leeuwen, Frank N; de Bont, Eveline S J M.

Affiliation

van der Sligte NE; Division of Pediatric Oncology/Hematology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Proteomics ; 15(7): 1245-54, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25422122

Subject(s)

Precursor Cell Lymphoblastic Leukemia-Lymphoma/enzymology; Protein Kinases/metabolism; Adolescent; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Child; Drug Discovery; Humans; Molecular Targeted Therapy; Phosphoproteins/metabolism; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy; Protein Interaction Maps; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/therapeutic use; Protein Processing, Post-Translational; Signal Transduction

Key words

Acute lymphoblastic leukemia; HGFR; Kinome profiling; Protein arrays; RON; Signal transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Precursor Cell Lymphoblastic Leukemia-Lymphoma Limits: Adolescent / Child / Humans Language: En Journal: Proteomics Journal subject: BIOQUIMICA Year: 2015 Document type: Article Affiliation country: Netherlands Country of publication: Germany

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