[2014 update of the GEFPICS' recommendations for HER2 status determination in breast cancers in France]. / Mise à jour 2014 des recommandations du GEFPICS pour l'évaluation du statut HER2 dans les cancers du sein en France.
Ann Pathol
; 34(5): 352-65, 2014 Oct.
Article
in Fr
| MEDLINE
| ID: mdl-25439988
ABSTRACT
International guidelines on HER2 determination in breast cancer have just been updated by the American Society of Clinical Oncology (ASCO) and College of American Pathologists (CAP), on the basis of more than ten-year practice, results of clinical trials and concordance studies. The GEFPICS group, composed of expert pathologists in breast cancer, herein presents these recommendations, adapted to the French routine practice. These guidelines highlight the possible diagnosis difficulties with regards to HER2 status determination, such as intra-tumor heterogeneity, special histological subtypes and biomarker re-evaluation during metastatic relapse. Pre-analytical issues and updated scoring criteria (especially for equivocal cases) are detailed, in order to decrease the occurrence of false negative cases. In the era of personalized medicine, pathologists are more than ever involved in the quality of oncotheranostic biomarker evaluation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Biomarkers, Tumor
/
Receptor, ErbB-2
Type of study:
Guideline
/
Prognostic_studies
Limits:
Female
/
Humans
Country/Region as subject:
Europa
Language:
Fr
Journal:
Ann Pathol
Year:
2014
Document type:
Article
Affiliation country:
France
Publication country:
FR
/
FRANCE
/
FRANCIA
/
FRANÇA