Inhibition of topoisomerases by fredericamycin A.

Latham, M D; King, C K; Gorycki, P; Macdonald, T L; Ross, W E

Latham, M D; King, C K; Gorycki, P; Macdonald, T L; Ross, W E.

Affiliation

Latham MD; Department of Pharmacology, University of Florida, Gainesville 32610.

Cancer Chemother Pharmacol ; 24(3): 167-71, 1989.

Article in En | MEDLINE | ID: mdl-2544307

Subject(s)

Antibiotics, Antineoplastic/pharmacology; Topoisomerase I Inhibitors; Animals; Antibiotics, Antineoplastic/toxicity; DNA Damage; DNA Polymerase II/antagonists & inhibitors; DNA, Neoplasm/biosynthesis; DNA, Neoplasm/drug effects; Dose-Response Relationship, Drug; Etoposide/pharmacology; Isoquinolines/pharmacology; Isoquinolines/toxicity; Leukemia L1210/enzymology; Mice; Spiro Compounds/pharmacology; Spiro Compounds/toxicity; Time Factors; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Topoisomerase I Inhibitors / Antibiotics, Antineoplastic Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cancer Chemother Pharmacol Year: 1989 Document type: Article Country of publication: Germany

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