Axonal transport declines with age in two distinct phases separated by a period of relative stability.

Milde, Stefan; Adalbert, Robert; Elaman, M Handan; Coleman, Michael P

Milde, Stefan; Adalbert, Robert; Elaman, M Handan; Coleman, Michael P.

Affiliation

Milde S; Signalling ISP, The Babraham Institute, Babraham Research Campus, Cambridge, UK.
Adalbert R; Signalling ISP, The Babraham Institute, Babraham Research Campus, Cambridge, UK.
Elaman MH; Signalling ISP, The Babraham Institute, Babraham Research Campus, Cambridge, UK.
Coleman MP; Signalling ISP, The Babraham Institute, Babraham Research Campus, Cambridge, UK. Electronic address: michael.coleman@babraham.ac.uk.

Neurobiol Aging ; 36(2): 971-81, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25443288

Subject(s)

Aging/physiology; Axonal Transport/physiology; Neurodegenerative Diseases/etiology; Aging/pathology; Animals; Axons/metabolism; Axons/pathology; Female; Humans; Male; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria/metabolism; Molecular Imaging; Nerve Regeneration; Neurodegenerative Diseases/metabolism; Nicotinamide-Nucleotide Adenylyltransferase/physiology; Optical Imaging; Peripheral Nerves/metabolism; Tibial Nerve/physiology

Key words

Aging; Axon regeneration; Axonal transport; Fluorescence live imaging; Mitochondrial transport; Nicotinamide mononucleotide Adenylyltransferase 2

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Axonal Transport / Aging / Neurodegenerative Diseases Limits: Animals / Female / Humans / Male Language: En Journal: Neurobiol Aging Year: 2015 Document type: Article Affiliation country: United kingdom Country of publication: United States

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