PKA is required for the modulation of spinal nociceptive information related to ephrinB-EphB signaling in mice.

Zhou, X-L; Wang, Y; Zhang, C-J; Yu, L-N; Cao, J-L; Yan, M

Zhou, X-L; Wang, Y; Zhang, C-J; Yu, L-N; Cao, J-L; Yan, M.

Affiliation

Zhou XL; Department of Anesthesiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China.
Wang Y; Jiangsu Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou 221000, China.
Zhang CJ; Department of Gastroenterology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China.
Yu LN; Department of Anesthesiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China.
Cao JL; Jiangsu Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou 221000, China.
Yan M; Department of Anesthesiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China; Jiangsu Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou 221000, China. Electronic address: yanminnina@126.com.

Neuroscience ; 284: 546-554, 2015 Jan 22.

Article in En | MEDLINE | ID: mdl-25453775

Subject(s)

Cyclic AMP-Dependent Protein Kinases/metabolism; Ephrin-B2/metabolism; Nociception/physiology; Receptors, Eph Family/metabolism; Spinal Cord/metabolism; Animals; Bone Neoplasms/drug therapy; Bone Neoplasms/physiopathology; Cell Line, Tumor; Cyclic AMP Response Element-Binding Protein/metabolism; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors; Disease Models, Animal; Ephrin-B2/administration & dosage; Hyperalgesia/drug therapy; Hyperalgesia/physiopathology; Inflammation/drug therapy; Inflammation/physiopathology; Male; Mice, Inbred C57BL; Neoplasm Transplantation; Neuralgia/drug therapy; Neuralgia/physiopathology; Nociception/drug effects; Phosphorylation/drug effects; Receptors, Eph Family/antagonists & inhibitors; Signal Transduction/drug effects; Spinal Cord/drug effects

Key words

EphB; central sensitization; ephrinB; hyperalgesia; protein kinase A

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Cyclic AMP-Dependent Protein Kinases / Receptors, Eph Family / Ephrin-B2 / Nociception Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neuroscience Year: 2015 Document type: Article Affiliation country: China Country of publication: United States

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