An efficient synthesis and biological screening of benzofuran  and benzo[d]isothiazole derivatives for Mycobacterium tuberculosis  DNA GyrB inhibition.

Reddy, Kummetha Indrasena; Srihari, Konduri; Renuka, Janupally; Sree, Komanduri Shruthi; Chuppala, Aruna; Jeankumar, Variam Ullas; Sridevi, Jonnalagadda Padma; Babu, Kondra Sudhakar; Yogeeswari, Perumal; Sriram, Dharmarajan

An efficient synthesis and biological screening of benzofuran and benzo[d]isothiazole derivatives for Mycobacterium tuberculosis DNA GyrB inhibition.

Reddy, Kummetha Indrasena; Srihari, Konduri; Renuka, Janupally; Sree, Komanduri Shruthi; Chuppala, Aruna; Jeankumar, Variam Ullas; Sridevi, Jonnalagadda Padma; Babu, Kondra Sudhakar; Yogeeswari, Perumal; Sriram, Dharmarajan.

Affiliation

Reddy KI; Department of Chemistry, Sri Krishnadevaraya University, Anantapur 515055, India.
Srihari K; Department of Chemistry, Sri Krishnadevaraya University, Anantapur 515055, India.
Renuka J; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawaharnagar, Shameerpet, Hyderabad 500078, India.
Sree KS; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawaharnagar, Shameerpet, Hyderabad 500078, India.
Chuppala A; Department of Chemistry, Sri Krishnadevaraya University, Anantapur 515055, India.
Jeankumar VU; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawaharnagar, Shameerpet, Hyderabad 500078, India.
Sridevi JP; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawaharnagar, Shameerpet, Hyderabad 500078, India.
Babu KS; Department of Chemistry, Sri Krishnadevaraya University, Anantapur 515055, India.
Yogeeswari P; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawaharnagar, Shameerpet, Hyderabad 500078, India.
Sriram D; Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawaharnagar, Shameerpet, Hyderabad 500078, India. Electronic address: dsriram@hyderabad.bits-pilani.ac.in.

Bioorg Med Chem ; 22(23): 6552-6563, 2014 Dec 01.

Article in En | MEDLINE | ID: mdl-25456076

Subject(s)

Antitubercular Agents/pharmacology; Benzofurans/pharmacology; Benzothiazoles/pharmacology; DNA Gyrase/metabolism; Mycobacterium tuberculosis/enzymology; Piperazines/pharmacology; Topoisomerase II Inhibitors/chemical synthesis; Topoisomerase II Inhibitors/pharmacology; Animals; Antitubercular Agents/chemical synthesis; Antitubercular Agents/chemistry; Benzofurans/chemical synthesis; Benzofurans/chemistry; Benzothiazoles/chemical synthesis; Benzothiazoles/chemistry; Cell Line; Dose-Response Relationship, Drug; Humans; Macrophages/drug effects; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mycobacterium tuberculosis/drug effects; Piperazines/chemical synthesis; Piperazines/chemistry; Structure-Activity Relationship; Topoisomerase II Inhibitors/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Benzofurans / DNA Gyrase / Benzothiazoles / Topoisomerase II Inhibitors / Mycobacterium tuberculosis / Antitubercular Agents Type of study: Diagnostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Document type: Article Affiliation country: India Country of publication: United kingdom

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