Comparative in vivo and in vitro analysis of possible estrogenic effects of perfluorooctanoic acid.

Yao, Pei-Li; Ehresman, David J; Rae, Jessica M Caverly; Chang, Shu-Ching; Frame, Steven R; Butenhoff, John L; Kennedy, Gerald L; Peters, Jeffrey M

Yao, Pei-Li; Ehresman, David J; Rae, Jessica M Caverly; Chang, Shu-Ching; Frame, Steven R; Butenhoff, John L; Kennedy, Gerald L; Peters, Jeffrey M.

Affiliation

Yao PL; Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.
Ehresman DJ; Medical Department, 3 M Company, St. Paul, MN 55144, USA.
Rae JM; Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19701, USA.
Chang SC; Medical Department, 3 M Company, St. Paul, MN 55144, USA.
Frame SR; Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19701, USA.
Butenhoff JL; Medical Department, 3 M Company, St. Paul, MN 55144, USA.
Kennedy GL; Consultant to DuPont Company, Wilmington, DE 19805, USA.
Peters JM; Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: jmp21@psu.edu.

Toxicology ; 326: 62-73, 2014 Dec 04.

Article in En | MEDLINE | ID: mdl-25456267

Subject(s)

Caprylates/toxicity; Environmental Pollutants/toxicity; Fluorocarbons/toxicity; Receptors, Estrogen/drug effects; Uterus/drug effects; Vagina/drug effects; Animals; Cell Line, Tumor; Cell Proliferation/drug effects; Estradiol/pharmacology; Estrogen Receptor alpha/drug effects; Estrogen Receptor alpha/genetics; Estrogen Receptor alpha/metabolism; Estrogens/pharmacology; Female; Gene Expression Regulation; Genes, Reporter; Humans; Mice; Organ Size; Receptors, Estrogen/genetics; Receptors, Estrogen/metabolism; Response Elements; Transfection; Uterus/metabolism; Uterus/pathology; Vagina/metabolism; Vagina/pathology

Key words

Estrogen receptor; Perfluorooctanoate; Uterus

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterus / Vagina / Caprylates / Receptors, Estrogen / Environmental Pollutants / Fluorocarbons Limits: Animals / Female / Humans Language: En Journal: Toxicology Year: 2014 Document type: Article Affiliation country: United States Country of publication: Ireland

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