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Design, synthesis and evaluation of novel 2-(1H-imidazol-2-yl) pyridine Sorafenib derivatives as potential BRAF inhibitors and anti-tumor agents.
Jiao, Yu; Xin, Bo-Tao; Zhang, Yanmin; Wu, Jianbing; Lu, Xiaolin; Zheng, Ying; Tang, Weifang; Zhou, Xiang.
Affiliation
  • Jiao Y; Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198 Jiang Su, China.
  • Xin BT; Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands.
  • Zhang Y; Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198 Jiang Su, China.
  • Wu J; Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198 Jiang Su, China.
  • Lu X; Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198 Jiang Su, China.
  • Zheng Y; Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198 Jiang Su, China.
  • Tang W; Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198 Jiang Su, China.
  • Zhou X; Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198 Jiang Su, China. Electronic address: stephanie055@163.com.
Eur J Med Chem ; 90: 170-83, 2015 Jan 27.
Article in En | MEDLINE | ID: mdl-25461318
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Pyridines / Drug Design / Niacinamide / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors / Imidazoles / Neoplasms, Experimental / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Eur J Med Chem Year: 2015 Document type: Article Affiliation country: China Country of publication: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Pyridines / Drug Design / Niacinamide / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors / Imidazoles / Neoplasms, Experimental / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Eur J Med Chem Year: 2015 Document type: Article Affiliation country: China Country of publication: France