Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes.

Kudo, Toshiyuki; Endo, Yumiko; Taguchi, Rina; Yatsu, Masami; Ito, Kiyomi

Kudo, Toshiyuki; Endo, Yumiko; Taguchi, Rina; Yatsu, Masami; Ito, Kiyomi.

Affiliation

Kudo T; Research Institute of Pharmaceutical Sciences, Musashino University , Tokyo , Japan.

Xenobiotica ; 45(5): 413-9, 2015 May.

Article in En | MEDLINE | ID: mdl-25470432

Subject(s)

Cryopreservation; Cytochrome P-450 Enzyme System/metabolism; Hepatocytes/enzymology; Metronidazole/pharmacology; Adult; Cell Line, Tumor; Cell Survival/drug effects; Cytochrome P-450 Enzyme System/genetics; Female; Gene Expression Regulation, Enzymologic/drug effects; Hepatocytes/drug effects; Humans; Isoenzymes/genetics; Isoenzymes/metabolism; Male; RNA, Messenger/genetics; RNA, Messenger/metabolism; Receptors, Cytoplasmic and Nuclear/genetics; Receptors, Cytoplasmic and Nuclear/metabolism; Tissue Donors; Young Adult

Key words

Cryopreserved human hepatocytes; Hepa RG cells; cytochrome P450; drug-drug interactions; metronidazole; nuclear receptors

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cryopreservation / Hepatocytes / Cytochrome P-450 Enzyme System / Metronidazole Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Xenobiotica Year: 2015 Document type: Article Affiliation country: Japan Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google