Risk factors associated with hypersensitivity reactions to cetuximab: anti-cetuximab IgE detection as screening test.
Future Oncol
; 10(14): 2133-40, 2014 Nov.
Article
in En
| MEDLINE
| ID: mdl-25471028
ABSTRACT
AIM:
To describe the factors associated with a high risk of a hypersensitivity reaction to cetuximab. PATIENTS &METHODS:
We retrospectively studied a cohort of patients living in Normandy (France) treated with cetuximab.RESULTS:
Among the 229 treated patients, 24 (10.5%) had a hypersensitivity reaction to cetuximab, including 11 grade 3-5 reactions. Detection of anti-cetuximab IgE could be performed in 108 patients. Anti-cetuximab IgE was found in 13 of 17 patients (76.5%) who had a hypersensitivity reaction to cetuximab compared with 17 of 91 control patients (18.7%; adjusted odds ratio 14.99; 95% CI 3.59-62.63). No clinical criteria predicted the risk of allergy to cetuximab.CONCLUSION:
Anti-cetuximab IgE may help physicians identify patients at risk of a hypersensitivity reaction to cetuximab.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin E
/
Drug Hypersensitivity
/
Antibodies, Monoclonal, Humanized
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Humans
Country/Region as subject:
Europa
Language:
En
Journal:
Future Oncol
Year:
2014
Document type:
Article
Affiliation country:
France
Country of publication:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM