Surfactant dysfunction and lung inflammation in the female mouse model of lymphangioleiomyomatosis.

Atochina-Vasserman, Elena N; Guo, Chang-Jiang; Abramova, Elena; Golden, Thea N; Sims, Michael; James, Melane L; Beers, Michael F; Gow, Andrew J; Krymskaya, Vera P

Atochina-Vasserman, Elena N; Guo, Chang-Jiang; Abramova, Elena; Golden, Thea N; Sims, Michael; James, Melane L; Beers, Michael F; Gow, Andrew J; Krymskaya, Vera P.

Affiliation

Atochina-Vasserman EN; 1 Airway Biology Initiative and.
Guo CJ; 2 Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; and.
Abramova E; 3 Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey.
Golden TN; 3 Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey.
Sims M; 3 Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey.
James ML; 2 Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; and.
Beers MF; 1 Airway Biology Initiative and.
Gow AJ; 2 Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; and.
Krymskaya VP; 2 Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; and.

Am J Respir Cell Mol Biol ; 53(1): 96-104, 2015 Jul.

Article in En | MEDLINE | ID: mdl-25474372

Subject(s)

Lymphangioleiomyomatosis/metabolism; Lymphangioleiomyomatosis/pathology; Pulmonary Alveoli/metabolism; Pulmonary Alveoli/pathology; Animals; Bronchoalveolar Lavage; Cytokines/genetics; Cytokines/metabolism; Disease Models, Animal; Female; Inflammation/genetics; Inflammation/metabolism; Inflammation/pathology; Lymphangioleiomyomatosis/genetics; Matrix Metalloproteinase 3/genetics; Matrix Metalloproteinase 3/metabolism; Matrix Metalloproteinase 9/genetics; Matrix Metalloproteinase 9/metabolism; Mice; Mice, Mutant Strains; Nitric Oxide/genetics; Nitric Oxide/metabolism; Nitric Oxide Synthase Type II/genetics; Nitric Oxide Synthase Type II/metabolism; Pulmonary Surfactant-Associated Protein A/genetics; Pulmonary Surfactant-Associated Protein A/metabolism; Pulmonary Surfactant-Associated Protein D/genetics; Pulmonary Surfactant-Associated Protein D/metabolism; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins/deficiency; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism

Key words

animal models; interstitial lung disease; nitric oxide; surfactant protein-D; tuberous sclerosis complex 2

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Alveoli / Lymphangioleiomyomatosis Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2015 Document type: Article Country of publication: United States

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