Rho GTPase independent regulation of ATM activation and cell survival by the RhoGEF Net1A.

Oh, Wonkyung; Frost, Jeffrey A

Oh, Wonkyung; Frost, Jeffrey A.

Affiliation

Oh W; a Department of Integrative Biology and Pharmacology ; University of Texas Health Science Center at Houston ; Houston , TX USA.

Cell Cycle ; 13(17): 2765-72, 2014.

Article in En | MEDLINE | ID: mdl-25486363

Subject(s)

Ataxia Telangiectasia Mutated Proteins/metabolism; Oncogene Proteins/metabolism; Rho Guanine Nucleotide Exchange Factors/metabolism; rhoA GTP-Binding Protein/metabolism; rhoB GTP-Binding Protein/metabolism; Cell Survival/radiation effects; DNA Breaks, Double-Stranded; DNA Damage; Histones/metabolism; Humans; MCF-7 Cells; Protein Isoforms/metabolism; Radiation, Ionizing; Signal Transduction/radiation effects

Key words

ATM; ATM, ataxia-telangiectasia mutated; DNA damage; DNA-PK, DNA dependent protein kinase; DSB, double strand break; IR, ionizing radiation; Net1; Net1, neuroepithelial transforming gene 1; RhoGEF, Rho guanine nucleotide exchange factor; breast cancer; ionizing radiation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oncogene Proteins / RhoA GTP-Binding Protein / RhoB GTP-Binding Protein / Ataxia Telangiectasia Mutated Proteins / Rho Guanine Nucleotide Exchange Factors Limits: Humans Language: En Journal: Cell Cycle Year: 2014 Document type: Article Country of publication: United States

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