Recent progress in studies of factors that elicit pancreatic ß-cell expansion.
Protein Cell
; 6(2): 81-7, 2015 Feb.
Article
in En
| MEDLINE
| ID: mdl-25492376
ABSTRACT
The loss of or decreased functional pancreatic ß-cell is a major cause of type 1 and type 2 diabetes. Previous studies have shown that adult ß-cells can maintain their ability for a low level of turnover through replication and neogenesis. Thus, a strategy to prevent and treat diabetes would be to enhance the ability of ß-cells to increase the mass of functional ß-cells. Consequently, much effort has been devoted to identify factors that can effectively induce ß-cell expansion. This review focuses on recent reports on small molecules and protein factors that have been shown to promote ß-cell expansion.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Proliferation
/
Diabetes Mellitus, Type 1
/
Diabetes Mellitus, Type 2
/
Insulin-Secreting Cells
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Protein Cell
Journal subject:
BIOQUIMICA
Year:
2015
Document type:
Article
Affiliation country:
China