A minute amount of s-puckered sugars is sufficient for (6-4) photoproduct formation at the dinucleotide level.
J Org Chem
; 80(1): 615-9, 2015 Jan 02.
Article
in En
| MEDLINE
| ID: mdl-25496131
ABSTRACT
The di-2'-α-fluoro analogue of thymidylyl(3',5')thymidine, synthesized to probe the effect of a minimum amount of S conformer on the photoreactivity of dinucleotides, is endowed with only 3% and 8% of S sugar conformation at its 5'- and 3'-end, respectively. This analogue gives rise to the (6-4) photoproduct as efficiently as the dithymine dinucleotide (74% and 66% at the 5'- and 3'-end, respectively) under 254 nm. Our results suggest that the 5'-N, 3'-S conformer gives rise to the (6-4) photoproduct.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carbohydrates
/
Dinucleoside Phosphates
Language:
En
Journal:
J Org Chem
Year:
2015
Document type:
Article
Affiliation country:
France