Local destabilization of the metal-binding region in human copper-zinc superoxide dismutase by remote mutations is a possible determinant for progression of ALS.

Hennig, Janosch; Andrésen, Cecilia; Museth, A Katrine; Lundström, Patrik; Tibell, Lena A E; Jonsson, Bengt-Harald

Hennig, Janosch; Andrésen, Cecilia; Museth, A Katrine; Lundström, Patrik; Tibell, Lena A E; Jonsson, Bengt-Harald.

Affiliation

Hennig J; Division of Molecular Biotechnology, Department of Physics, Chemistry and Biology, Linköping University , SE-581 83, Linköping, Sweden.

Biochemistry ; 54(2): 323-33, 2015 Jan 20.

Article in En | MEDLINE | ID: mdl-25496420

Subject(s)

Amyotrophic Lateral Sclerosis/genetics; Point Mutation; Superoxide Dismutase/chemistry; Superoxide Dismutase/genetics; Amyotrophic Lateral Sclerosis/metabolism; Binding Sites; Copper/metabolism; Humans; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Aggregation, Pathological/genetics; Protein Aggregation, Pathological/metabolism; Protein Structure, Secondary; Superoxide Dismutase/metabolism; Zinc/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Superoxide Dismutase / Point Mutation / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Journal: Biochemistry Year: 2015 Document type: Article Affiliation country: Sweden

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