MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics.

Yang, Y; Nadanaciva, S; Will, Y; Woodhead, J L; Howell, B A; Watkins, P B; Siler, S Q

Yang, Y; Nadanaciva, S; Will, Y; Woodhead, J L; Howell, B A; Watkins, P B; Siler, S Q.

Affiliation

Yang Y; Institute for Drug Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA.

Pharm Res ; 32(6): 1975-92, 2015 Jun.

Article in En | MEDLINE | ID: mdl-25504454

Subject(s)

Chemical and Drug Induced Liver Injury/etiology; Energy Metabolism/drug effects; Hepatocytes/drug effects; Liver/drug effects; Mitochondria, Liver/drug effects; Models, Biological; Adenosine Triphosphate/metabolism; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/toxicity; Cell Respiration/drug effects; Chemical and Drug Induced Liver Injury/metabolism; Chemical and Drug Induced Liver Injury/pathology; Computer Simulation; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes/metabolism; Hepatocytes/pathology; Humans; Hydrogen-Ion Concentration; Liver/metabolism; Liver/pathology; Membrane Potential, Mitochondrial/drug effects; Mitochondria, Liver/metabolism; Mitochondria, Liver/pathology; Oxygen Consumption/drug effects; Risk Assessment; Rotenone/toxicity; Time Factors; Uncoupling Agents/toxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mitochondria, Liver / Hepatocytes / Energy Metabolism / Chemical and Drug Induced Liver Injury / Liver / Models, Biological Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Pharm Res Year: 2015 Document type: Article Affiliation country: United States

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