Preferential expression of OVOL1 in inner root sheath of hair, sebaceous gland, eccrine duct and their neoplasms in human skin.
Fukuoka Igaku Zasshi
; 105(8): 166-73, 2014 Aug.
Article
in En
| MEDLINE
| ID: mdl-25509883
ABSTRACT
OVOL1 is an important transcription factor for epidermal keratinization, which suppresses proliferation and switches on the differentiation of keratinocytes. A recent genome-wide association study has revealed that OVOL1 is one of the genes associated with susceptibility to atopic dermatitis. Although it is known to be expressed in murine skin and hair follicles, no investigations have focused on its localization in human skin. In the present study, we thus immunolocalized the expression of OVOL1 in normal and diseased human skin. In normal human skin, OVOL1 was preferentially expressed in the suprabasal layer of the epidermis, inner root sheath of hair, mature sebocytes and the ductal portion of the eccrine glands. Compared to this, no remarkable change in the expression of OVOL1 was observed among inflammatory skin diseases. The expression of OVOL1 was evident in eccrine poroma and hidradenoma. Moreover, it was overexpressed in Bowen's disease and sebaceous adenoma, in sharp contrast to its downregulation in their more malignant counterparts, squamous cell carcinoma and sebaceous carcinoma. OVOL1 may play an important role in human skin morphogenesis and tumorigenesis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sebaceous Glands
/
Skin Neoplasms
/
Transcription Factors
/
DNA-Binding Proteins
/
Hair
Language:
En
Journal:
Fukuoka Igaku Zasshi
Journal subject:
MEDICINA
Year:
2014
Document type:
Article
Publication country:
JAPAN
/
JAPON
/
JAPÃO
/
JP