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Methods to Make Homogenous Antibody Drug Conjugates.
Kline, Toni; Steiner, Alexander R; Penta, Kalyani; Sato, Aaron K; Hallam, Trevor J; Yin, Gang.
Affiliation
  • Kline T; Sutro Biopharma, Inc, 310 Utah Ave Ste 150, South San Francisco, California, 94080, USA.
  • Steiner AR; Sutro Biopharma, Inc, 310 Utah Ave Ste 150, South San Francisco, California, 94080, USA.
  • Penta K; Sutro Biopharma, Inc, 310 Utah Ave Ste 150, South San Francisco, California, 94080, USA.
  • Sato AK; Sutro Biopharma, Inc, 310 Utah Ave Ste 150, South San Francisco, California, 94080, USA.
  • Hallam TJ; Sutro Biopharma, Inc, 310 Utah Ave Ste 150, South San Francisco, California, 94080, USA.
  • Yin G; Sutro Biopharma, Inc, 310 Utah Ave Ste 150, South San Francisco, California, 94080, USA. gyin@sutrobio.com.
Pharm Res ; 32(11): 3480-93, 2015 Nov.
Article in En | MEDLINE | ID: mdl-25511917
ABSTRACT
Antibody drug conjugates (ADCs) have progressed from hypothesis to approved therapeutics in less than 30 years, and the technologies available to modify both the antibodies and the cytotoxic drugs are expanding rapidly. For reasons well reviewed previously, the field is trending strongly toward homogeneous, defined antibody conjugation. In this review we present the antibody and small molecule chemistries that are currently used and being explored to develop specific, homogenous ADCs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Engineering / Technology, Pharmaceutical / Immunoconjugates / Small Molecule Libraries / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: Pharm Res Year: 2015 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Engineering / Technology, Pharmaceutical / Immunoconjugates / Small Molecule Libraries / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: Pharm Res Year: 2015 Document type: Article Affiliation country: United States