Methods to Make Homogenous Antibody Drug Conjugates.
Pharm Res
; 32(11): 3480-93, 2015 Nov.
Article
in En
| MEDLINE
| ID: mdl-25511917
ABSTRACT
Antibody drug conjugates (ADCs) have progressed from hypothesis to approved therapeutics in less than 30 years, and the technologies available to modify both the antibodies and the cytotoxic drugs are expanding rapidly. For reasons well reviewed previously, the field is trending strongly toward homogeneous, defined antibody conjugation. In this review we present the antibody and small molecule chemistries that are currently used and being explored to develop specific, homogenous ADCs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Engineering
/
Technology, Pharmaceutical
/
Immunoconjugates
/
Small Molecule Libraries
/
Antibodies, Monoclonal
Limits:
Animals
/
Humans
Language:
En
Journal:
Pharm Res
Year:
2015
Document type:
Article
Affiliation country:
United States