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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases.
Tsai, Shengdar Q; Zheng, Zongli; Nguyen, Nhu T; Liebers, Matthew; Topkar, Ved V; Thapar, Vishal; Wyvekens, Nicolas; Khayter, Cyd; Iafrate, A John; Le, Long P; Aryee, Martin J; Joung, J Keith.
Affiliation
  • Tsai SQ; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA USA.
  • Zheng Z; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA USA.
  • Nguyen NT; Department of Pathology, Harvard Medical School, Boston, MA USA.
  • Liebers M; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA USA.
  • Topkar VV; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA USA.
  • Thapar V; Department of Pathology, Harvard Medical School, Boston, MA USA.
  • Wyvekens N; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Khayter C; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA USA.
  • Iafrate AJ; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA USA.
  • Le LP; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA USA.
  • Aryee MJ; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA USA.
  • Joung JK; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA USA.
Nat Biotechnol ; 33(2): 187-197, 2015 Feb.
Article in En | MEDLINE | ID: mdl-25513782
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Guide, Kinetoplastida / DNA Breaks, Double-Stranded / CRISPR-Cas Systems Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Biotechnol Journal subject: BIOTECNOLOGIA Year: 2015 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Guide, Kinetoplastida / DNA Breaks, Double-Stranded / CRISPR-Cas Systems Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Biotechnol Journal subject: BIOTECNOLOGIA Year: 2015 Document type: Article