New synthetic sulfone derivatives inhibit growth, adhesion and the leucine arylamidase APE2 gene expression of Candida albicans in vitro.

Staniszewska, Monika; Bondaryk, Malgorzata; Ochal, Zbigniew

Staniszewska, Monika; Bondaryk, Malgorzata; Ochal, Zbigniew.

Affiliation

Staniszewska M; Independent Laboratory of Streptomyces and Fungi Imperfecti, National Institute of Public Health-National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland. Electronic address: mstaniszewska@pzh.gov.pl.
Bondaryk M; Independent Laboratory of Streptomyces and Fungi Imperfecti, National Institute of Public Health-National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland.
Ochal Z; Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.

Bioorg Med Chem ; 23(2): 314-21, 2015 Jan 15.

Article in En | MEDLINE | ID: mdl-25515956

Subject(s)

Antifungal Agents/chemical synthesis; Candida albicans/drug effects; Gene Expression Regulation, Fungal/drug effects; Sulfones/chemistry; Antifungal Agents/chemistry; Antifungal Agents/pharmacology; Caco-2 Cells; Candida albicans/enzymology; Candida albicans/genetics; Cell Adhesion/drug effects; Fungal Proteins/genetics; Fungal Proteins/metabolism; Humans; Hydrazines/chemistry; Microbial Sensitivity Tests; Structure-Activity Relationship; Sulfones/chemical synthesis; Sulfones/pharmacology

Key words

APE2; Adhesion; Anti-virulence agents; Candida albicans; Morphogenesis; Sulfone derivatives

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Candida albicans / Gene Expression Regulation, Fungal / Antifungal Agents Type of study: Guideline Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article Country of publication: United kingdom

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