Low and fixed dose of hydroxyurea is effective and safe in patients with HbSß(+) thalassemia with IVS1-5(GâC) mutation.

Dehury, Snehadhini; Purohit, Prasanta; Patel, Siris; Meher, Satyabrata; Kullu, Bipin Kishore; Sahoo, Lulup Kumar; Patel, Nayan Kumar; Mohapatra, Alok Kumar; Das, Kishalaya; Patel, Dilip Kumar

Low and fixed dose of hydroxyurea is effective and safe in patients with HbSß(+) thalassemia with IVS1-5(GâC) mutation.

Dehury, Snehadhini; Purohit, Prasanta; Patel, Siris; Meher, Satyabrata; Kullu, Bipin Kishore; Sahoo, Lulup Kumar; Patel, Nayan Kumar; Mohapatra, Alok Kumar; Das, Kishalaya; Patel, Dilip Kumar.

Affiliation

Dehury S; Sickle Cell Clinic and Molecular Biology Laboratory, Veer Surendra Sai Medical College, Burla, Sambalpur, Odisha, India.

Pediatr Blood Cancer ; 62(6): 1017-23, 2015 Jun.

Article in En | MEDLINE | ID: mdl-25546091

Subject(s)

Hemoglobin, Sickle/genetics; Hydroxyurea/administration & dosage; Mutation; Thalassemia/drug therapy; Adolescent; Adult; Child; Child, Preschool; Female; Fertility; Hemoglobin, Sickle/analysis; Humans; Hydroxyurea/adverse effects; Male; Prospective Studies; Thalassemia/blood; Thalassemia/genetics

Key words

HbF; HbSß+ thalassemia; fertility; hydroxyurea; low dose; vaso occlusive crisis (VOC)

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thalassemia / Hemoglobin, Sickle / Hydroxyurea / Mutation Type of study: Observational_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Language: En Journal: Pediatr Blood Cancer Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2015 Document type: Article Affiliation country: India Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google