[Caffeoylquinic acid derivatives from stems of Akebia trifoliata].

ABSTRACT

OBJECTIVE: To study the chemical constituents from Akebia trifoliata stems. METHODS: The compounds were isolated and purified by column chromatography, and their structures were determined through spectroscopic techniques and physicochemical properties. RESULTS: Six compounds were isolated from the stems of Akebia trifolita and identified as cryptochlorogenic acid methyl ester (1), neochlorogenic acid methyl ester (2), chlorogenic acid methyl ester (3), methyl 3,5-di-O-caffeoyl quinate (4), methyl 3,4-di-O-caffeoyl quinate (5) and methyl 4,5-di-O-caffeoyl quinate (6). CONCLUSION: All compounds are isolated from Akebia genus for the first time. Compounds 1,5 and 6 demonstrate obvious inhibitory activities against α-glucosidase.