Cytotoxicity of synthesized Iron Oxide nanoparticles: toward novel biomarkers of colon cancer.
Annu Int Conf IEEE Eng Med Biol Soc
; 2014: 6179-82, 2014.
Article
in En
| MEDLINE
| ID: mdl-25571408
ABSTRACT
In this paper we present the preliminary results of a novel biological analysis platform for early colon cancer detection using magnetic separation of magnetized markers. The platform consists of a microfluidic structure integrated with biosensors. Super-Paramagnetic Iron Oxide nanoparticles (SPIO-NPs) were functionalized with purified DNA Aptamer and their synthesis is described. In this paper, we also present the physicochemical results of the synthesized SPIO/Au-NPs characterized by TEM and XRD. Toxicity of our synthesized biomarkers on HCT116 cell line is discussed. Based on our findings, a concentration of 1mg/ml of our biomarkers added to 5 × 105 cells per well has no effect the viability of the human cells even after 24 hours.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biomarkers
/
Microfluidic Analytical Techniques
/
Ferrosoferric Oxide
/
Magnetite Nanoparticles
Limits:
Humans
Language:
En
Journal:
Annu Int Conf IEEE Eng Med Biol Soc
Year:
2014
Document type:
Article