Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses.
Front Biol (Beijing)
; 9(6): 423-436, 2014 Dec.
Article
in En
| MEDLINE
| ID: mdl-25580106
ABSTRACT
Between 15-20% of human cancers are associated with infection by oncogenic viruses. Oncogenic viruses, including HPV, HBV, HCV and HTLV-1, target mitochondria to influence cell proliferation and survival. Oncogenic viral gene products also trigger the production of reactive oxygen species which can elicit oxidative DNA damage and potentiate oncogenic host signaling pathways. Viral oncogenes may also subvert mitochondria quality control mechanisms such as mitophagy and metabolic adaptation pathways to promote virus replication. Here, we will review recent progress on viral regulation of mitophagy and metabolic adaptation and their roles in viral oncogenesis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Front Biol (Beijing)
Year:
2014
Document type:
Article
Affiliation country:
United States