N-(2,4)-dinitrophenyl-L-arginine Interacts with EphB4 and Functions as an EphB4 Kinase Modulator.

Kamstra, Rhiannon L; Freywald, Andrew; Floriano, Wely B

Kamstra, Rhiannon L; Freywald, Andrew; Floriano, Wely B.

Affiliation

Kamstra RL; Department of Chemistry, Lakehead University, Thunder Bay, ON, P7B 5E1, Canada.
Freywald A; Thunder Bay Regional Research Institute, Thunder Bay, ON, P7A 7T1, Canada.
Floriano WB; Department of Pathology, University of Saskatchewan, Saskatoon, SK, S7N 0W0, Canada.

Chem Biol Drug Des ; 86(4): 476-86, 2015 Oct.

Article in En | MEDLINE | ID: mdl-25581780

Subject(s)

Antineoplastic Agents/chemistry; Arginine/analogs & derivatives; Arginine/chemistry; Dinitrobenzenes/chemistry; Neoplasm Proteins/chemistry; Receptor, EphB4/chemistry; Carcinoma, Hepatocellular/drug therapy; Carcinoma, Hepatocellular/enzymology; Humans; Liver Neoplasms/drug therapy; Liver Neoplasms/enzymology; Neoplasm Proteins/metabolism; Receptor, EphB4/metabolism

Key words

Eph kinase; HierVLS; hepatocellular carcinoma receptor B4; receptor tyrosine kinase modulator; virtual ligand screening

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Receptor, EphB4 / Dinitrobenzenes / Neoplasm Proteins / Antineoplastic Agents Limits: Humans Language: En Journal: Chem Biol Drug Des Journal subject: BIOQUIMICA / FARMACIA / FARMACOLOGIA Year: 2015 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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