Harnessing medically relevant metals onto water-soluble subphthalocyanines: towards bimodal imaging and theranostics.
Dalton Trans
; 44(7): 3200-8, 2015 Feb 21.
Article
in En
| MEDLINE
| ID: mdl-25581854
ABSTRACT
Subphthalocyanine (SubPc), a putative fluorophore for optical imaging (OI), was conjugated to chelating ligands (DOTA, DTPA) affording water-soluble conjugates complexed with (non-radioactive) metals relevant to the following medical imaging techniques/therapies MRI (Gd), PET (Cu, Ga), SPECT (In, Ga, Lu), RIT (Cu, Lu, Y), and NCT (Gd). Magneto-optical properties of ditopic gadolinium species (and optical properties of other metal containing species) were examined (brightness (ε × ΦF) and relaxivity R1) and fluorescence confocal/biphoton microscopy studies were conducted.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Water
/
Indoles
/
Metals
Limits:
Humans
Language:
En
Journal:
Dalton Trans
Journal subject:
QUIMICA
Year:
2015
Document type:
Article
Affiliation country:
France